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Bioartificial cardiovascular patches and vessels from porcine collagen reinforced with nano/microfibers using stem cells and dynamic culture

Grant No.: NV19-02-00068, Cardiac and Cardiovascular systems	Grant Agency: Ministry of Health of the Czech Republic
Resolved in: 2019 - 2022
Principal investigator: prof. MUDr. Jan Pirk, DrSc. Institute for Clinical and Experimental Medicine	Co-investigators: Dr. Elena Filová Institute of Physiology of the CAS Dr. Monika Šupová Institute of Rock Structure and Mechanics of the CAS Dr. Roman Matějka Czech Technical University in Prague / Faculty of Biomedical Engineering
Description: During cardiovascular surgeries are small calibre vessel grafts and vascular patches required. The most suitable in this field are autologous tissues, whgich are often deficient. Allogeneic or aretificial materials are often thrombogenic. The aim of the project is to create vascular grafts and patches using collagen gels reinforced with nano/micro fibres, moulded into the required shape along with stem cells. These constructs will be remodelled in the bioreactor forming a new tissue. This construct will be decellularized to eliminate the immune response while retaining the support structure. In vivo verification in pigs will involve two surgeries. In the first surgery, a small amount of subcutaneous fat and blood will be collected from which stem and endothelial cells will be isolated for autologous colobization in the bioreactor. Then a second operation will be followed in which the patch/vascular replacement will be impalted onto a Carotis. After 4 weeks of clinical monitoring, implants will be remowed and histologically assessed for overall structure, patency and thrombogenicity.
ISVAV: (What is it?) Project in The Research and Development and Innovation System of the Czech Republic (in Czech only)